論文業績紹介

2017年

Sakai T, Sowa Y. Molecular-targeting therapies against quantitative abnormalities in gene expression with malignant tumors. Cancer Sci. 108:570-3, 2017.

Kawarazaki A, Horinaka M, Yasuda S, Numajiri T, Nishino K, Sakai T. Sulforaphane suppresses cell growth and collagen expression of keloid fibroblasts. Wound Repair Regen. 2017. [Epub ahead of print]

Akiyama M, Sowa Y, Taniguchi T, Watanabe M, Yogosawa S, Kitawaki J, Sakai T. Three-Combined Treatment, a Novel HDAC Inhibitor OBP-801/YM753, 5-Fluorouracil and Paclitaxel, Induces G2-Phase Arrest Through the p38 Pathway in Human Ovarian Cancer Cells. Oncol Res. 2017. [Epub ahead of print]

2016年

Tanaka R, Tomosugi M, Sakai T, Sowa Y. MEK Inhibitor Suppresses Expression of the miR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer Cells. Anticancer Res. 36:4537-43, 2016.

Nakamura T, Ishikawa H, Mutoh M, Wakabayashi K, Kawano A, Sakai T, Matsuura N. Coffee prevents proximal colorectal adenomas in Japanese men: a prospective cohort study. Eur J Cancer Prev. 25:388-94, 2016.

Toriyama S, Horinaka M, Yasuda S, Taniguchi T, Aono Y, Takamura T, Morioka Y, Miki T, Ukimura O, Sakai T. A histone deacetylase inhibitor OBP-801 and celecoxib synergistically inhibit the cell growth with apoptosis via a DR5-dependent pathway in bladder cancer cells. Mol Cancer Ther. 15:2066-75, 2016.

Taniguchi T, Iizumi Y, Watanabe M, Masuda M, Morita M, Aono Y, Toriyama S, Oishi M, Goi W, Sakai T. Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer. Cell Death Dis. 7:e2211, 2016.

Ikai A, Watanabe M, Sowa Y, Kishimoto M, Yanagisawa A, Fujiwara H, Otsuji E, Sakai T. Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer. Int J Oncol. 48:1297-304, 2016.

Ishikawa H, Mutoh M, Iwama T, Suzuki S, Abe T, Takeuchi Y, Nakamura T, Ezoe Y, Fujii G, Wakabayashi K, Nakajima T, Sakai T. Endoscopic management of familial adenomatous polyposis in patients refusing colectomy. Endoscopy. 48:51-5, 2016.

2015年

Ichikawa M, Sowa Y, Iizumi Y, Aono Y, Sakai T. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS One. 10:e0129851, 2015.

Tanaka R, Tomosugi M, Horinaka M, Sowa Y, Sakai T. Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells. PLoS One.10:e0125779, 2015.

Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T, Katoh N. PDK1 is a potential therapeutic target against angiosarcoma cells. J Dermatol Sci. 78: 44-50, 2015.

Sun Q, Yogosawa S, Iizumi Y, Sakai T, Sowa Y.The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL. Int J Oncol. 46: 389-94, 2015.

Goda AE, Erikson RL, Sakai T, Ahn JS, Kim BY. Preclinical evaluation of bortezomib/dipyridamole novel combination as a potential therapeutic modality for hematologic malignancies. Mol Oncol. 9: 309-22, 2015.

2014年

Wada M, Horinaka M, Yamazaki T, Katoh N, Sakai T. The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells. PLoS One. 9: e113217, 2014.

Horinaka M, Yoshida T, Tomosugi M, Yasuda S, Sowa Y, Sakai T. Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells. Sci Rep. 4: 6000, 2014.

Furutani A, Sowa Y, Fujiwara H, Otsuji E, Sakai T. The novel HDAC inhibitor OBP-801/YM753 enhances the effects of 5-fluorouracil with radiation on esophageal squamous carcinoma cells. Oncol Res. 21: 281-6, 2014.

Ishikawa H, Mutoh M, Suzuki S, Tokudome S, Saida Y, Abe T, Okamura S, Tajika M, Joh T, Tanaka S, Kudo SE, Matsuda T, Iimuro M, Yukawa T, Takayama T, Sato Y, Lee K, Kitamura S, Mizuno M, Sano Y, Gondo N, Sugimoto K, Kusunoki M, Goto C, Matsuura N, Sakai T, Wakabayashi K. The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. Gut. 63: 1755-9, 2014.

Koyama M, Sowa Y, Horinaka M, Goda AE, Fujiwara J, Sakai T. Peroxisome proliferator-activated receptor γ ligand troglitazone and TRAIL synergistically induce apoptosis. Oncol Rep. 31: 947-54, 2014.

Okumura N, Nakano S, Kay EP, Numata R, Ota A, Sowa Y, Sakai T, Ueno M, Kinoshita S, Koizumi N. Involvement of cyclin D and p27 in cell proliferation mediated by ROCK inhibitors Y-27632 and Y-39983 during corneal endothelium wound healing. Invest Ophthalmol Vis Sci. 55: 318-29, 2014.

2013年(追加分)

Koyama M, Sowa Y, Hitomi T, Iizumi Y, Watanabe M, Taniguchi T, Ichikawa M, Sakai T. Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. Oncol Rep. 29:779-84, 2013.

Iizumi Y, Oishi M, Taniguchi T, Goi W, Sowa Y, Sakai T. The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9. PLoS One. 8:e73219, 2013.

Ishikawa H, Wakabayashi K, Suzuki S, Mutoh M, Hirata K, Nakamura T, Takeyama I, Kawano A, Gondo N, Abe T, Tokudome S, Goto C, Matsuura N, Sakai T. Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial. Cancer Med. 2: 50-6, 2013.

Todo M, Horinaka M, Tomosugi M, Tanaka R, Ikawa H, Sowa Y, Ishikawa H, Fujiwara H, Otsuji E, Sakai T. Ibuprofen enhances TRAIL-induced apoptosis through DR5 upregulation. Oncol Rep. 30: 2379-84, 2013.

Yamada T, Horinaka M, Shinnoh M, Yoshioka T, Miki T, Sakai T. A novel HDAC inhibitor OBP-801 and a PI3K inhibitor LY294002 synergistically induce apoptosis via the suppression of survivin and XIAP in renal cell carcinoma. Int J Oncol. 43: 1080-6, 2013.

Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T. Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity. Cancer Res. 73:4050-60, 2013.

Goda AE, Koyama M, Sowa Y, Elokely KM, Yoshida T, Kim BY, Sakai T. Molecular mechanisms of the antitumor activity of SB225002: a novel microtubule inhibitor. Biochem Pharmacol. 85: 1741-52, 2013.

Watanabe M, Sowa Y, Yogosawa M, Sakai T. Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells. Cancer Sci. 104:687-93, 2013.

Oishi M, Iizumi Y, Taniguchi T, Goi W, Miki T, Sakai T. Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2. PLoS One. 8: e55922, 2013.

Yoshioka T, Yogosawa S, Yamada T, Kitawaki J, Sakai T. Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS. Gynecol Oncol. 129: 425-32, 2013.

Shinnoh M, Horinaka M, Yasuda T, Yoshikawa S, Morita M, Yamada T, Miki T, Sakai T. Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8. Int J Oncol. 42: 903-11, 2013.

2012年

Ishikawa H, Goto M, Matsuura N, Murakami Y, Goto C, Sakai T, Kanazawa K. A pilot, randomized, placebo-controlled, double-blind phase 0/biomarker study on effect of artepillin C-rich extract of Brazilian propolis in frequent colorectal adenoma polyp patients. J Am Coll Nutr. 31: 327-37, 2012.

Yogosawa S, Yamada Y, Yasuda S, Sun Q, Takizawa K, Sakai T. Dehydrozingerone, a structural analogue of curcumin, induces cell-cycle arrest at the G2/M phase and accumulates intracellular ROS in HT-29 human colon cancer cells. J Nat Prod. 75: 2088-93, 2012.

Yoshida T, Kakegawa J, Yamaguchi T, Hantani Y, Okajima N, Sakai T, Watanabe Y, Nakamura M. Identification and characterization of a novel chemotype MEK inhibitor able to alter the phosphorylation state of MEK1/2. Oncotarget. 3: 1533-45, 2012.

Tomosugi M, Sowa Y, Yasuda S, Tanaka R, te Riele H, Ikawa H, Koyama M, Sakai T. Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. Cancer Sci. 2012, 103: 2139-43.

Tophkhane C, Yang SH, Jiang Y, Ma Z, Subramaniam D, Anant S, Yogosawa S, Sakai T, Liu WG, Edgerton S, Thor A, Yang X. p53 inactivation upregulates p73 expression through E2F-1 mediated transcription. PLoS One. 7: e43564, 2012.

Taniguchi H, Horinaka M, Yoshida T, Yano K, Goda AE, Yasuda S, Wakada M, Sakai T. Targeting the glyoxalase pathway enhances TRAIL efficacy in cancer cells by downregulating the expression of antiapoptotic molecules. Mol Cancer Ther. 11: 2294-300, 2012.

Fujiwara J, Sowa Y, Horinaka M, Koyama M, Wakada M, Miki T, Sakai T. The anti-obesity drug orlistat promotes sensitivity to TRAIL by two different pathways in hormone-refractory prostate cancer cells. Int J Oncol. 40: 1483-91, 2012.

Izutani Y, Yogosawa S, Sowa Y, Sakai T. Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells. Int J Oncol. 40: 816-24, 2012.

Horinaka M, Yoshida T, Nakata S, Shiraishi T, Tomosugi M, Yoshikawa S, Wakada M, Sakai T. Aclarubicin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis through death receptor 5 upregulation. Cancer Sci. 103: 282-7, 2012.

2011年

Yamaguchi T, Kakefuda R, Tajima N, Sowa Y, Sakai T. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol. 39: 23-31, 2011.

Yano K, Horinaka M, Yoshida T, Yasuda T, Taniguchi H, Goda AE, Wakada M, Yoshikawa S, Nakamura T, Kawauchi A, Miki T, Sakai T. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Int J Oncol. 38: 365-74, 2011.

2010年

Kawano A, Ishikawa H, Akedo I, Nakamura T, Matsumoto K, Takayama H, Imaoka A, Umesaki Y, tanaka R, Otani T, Sakai T. Effect of Lactobacillus casei on Streptococcus bovis in faecal flora. BMJ Case Reports doi: 10.1136/bcr.06.2009.2019, 2010.

Kawano A, Ishikawa H, Kamano T, Kanoh M, Sakamoto K, Nakamura T, Otani T, Sakai T, Kono K. Significance of fecal deoxycholic acid concentration for colorectal tumor enlargement. Asian Pac J Cancer P. 11: 1541-46, 2010.

Frese-Schaper M, Schardt JA, Sakai T, Carboni GL, Schmid RA, Frese S. Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5. FEBS Lett. 584: 2867-71, 2010.

Nakamura T, Ishikawa H, Takeyama I, Kawano A, Ishiguro S, Otani T, Okuda T, Murakami Y, Sakai T, Matsuura N. Excessive fat restriction might promote the recurrence of colorectal tumors. Nutr Cancer 62: 154-63, 2010.

Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. Clin Cancer Res.16, 2320-32, 2010.

Uchiyama H, Sowa Y, Wakada M, Yogosawa M, Nakanishi R, Horinaka M, Shimazaki C, Taniwaki M, Sakai T. Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell leukemia Jurkat cells. Cancer Sci. 101, 728-34, 2010.

Horinaka M, Yoshida T, Kishi A, Akatani K, Yasuda T, Kouhara J, Wakada M, Sakai T. Lactobacillus strains induce TRAIL production and facilitate natural killer activity against cancer cells. FEBS Lett. 584, 577-82, 2010.

Matsui TA, Murata H, Sowa Y, Sakabe T, Koto K, Horie N, Tsuji Y, Sakai T, Kubo T. A novel MEK1/2 inhibitor induces G1/S cell cycle arrest in human fibrosarcoma cells. Oncol Rep. 24, 329-33, 2010.

Frese-Schaper M, Schardt JA, Sakai T, Carboni GL, Schmid RA, Frese S. Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5. FEBS Lett. 584, 2867-71, 2010.

Kume K, Iizumi Y, Shimada M, Ito Y, Kishi T, Yamaguchi Y, handa H. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Genes Cells 15, 339-49, 2010.

Ohsaka Y, Yogosawa S, Nakanishi R, Sakai T, Nishino H. Polymorphisms in promoter sequences of the p15INK4B and PTEN genes of normal Japanese individuals. Biochem Genet. 48, 970-86, 2010.

Yasuda S, Yogosawa S, Izutani Y, Nakamura Y, Watanabe H, Sakai T. Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells. Mol Nutr Food Res. 54, 559-65,2010.

2009年

Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, Sakai T. A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer. 2009 Nov 12;8(1):100.

Sugiyama H, Kumamoto T, Suganami A, Nakanishi W, Sowa Y, Takiguchi M, Ishikawa T, Tamura Y. Insight into estrogenicity of phytoestrogens using in silico simulation. Biochem Biophys Res Commun. 2009 Jan 30;379(1):139-44.

Kikuchi H, Ohtsuki T, Koyano T, Kowithayakorn T, Sakai T, Ishibashi M. Death receptor 5 targeting activity-guided isolation of isoflavones from Millettia brandisiana and Ardisia colorata and evaluation of ability to induce TRAIL-mediated apoptosis. Bioorg Med Chem. 2009 Feb 1;17(3):1181-6.

Huerta-Yepez S, Vega M, Escoto-Chavez SE, Murdock B, Sakai T, Baritaki S, Bonavida B.; Nitric oxide sensitizes tumor cells to TRAIL-induced apoptosis via inhibition of the DR5 transcription repressor Yin Yang 1.; Nitric Oxide. 2009 Feb;20(1):39-52. (Epub 2008 Aug 22).

2008年

Yoshida T, Horinaka M, Takara M, Tsuchihashi M, Mukai N, Wakada M, Sakai T. Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. Environ Health Prev Med. 2008 Sep;13(5):281-7. Epub 2008 Jul 31.

Kong D, Aoki S, Sowa Y, Sakai T, Kobayashi M. Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells. Mar Drugs. 2008;6(3):480-8.

Yasuda T, Yoshida T, Goda AE, Horinaka M, Yano K, Shiraishi T, Wakada M, Mizutani Y, Miki T, Sakai T. Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with TRAIL. Mol Cancer Res. 2008 Dec;6(12):1852-60.

Taniguchi H, Yoshida T, Horinaka M, Yasuda T, Goda AE, Konishi M, Wakada M, Kataoka K, Yoshikawa T, Sakai T. Baicalein overcomes TRAIL resistance via two different cell specific pathways in cancer cells but not in normal cells. Cancer Res. 2008 Nov 1;68(21):8918-27.

Yoshida T, Konishi M, Horinaka M, Yasuda T, Goda AE, Taniguchi H, Yano K, Wakada M, Sakai T.; Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis.; Biochem Biophys Res Commun. 2008 Oct 10;375(1):129-33.

Goda AE, Yoshida T, Horinaka M, Yasuda T, Shiraishi T, Wakada M, Sakai T.; Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole.; Oncogene. 2008 May 29;27(24):3435-45.

Shindoh N, Mori M, Terada Y, Oda K, Amino N, Kita A, Taniguchi M, Sohda KY, Nagai K, Sowa Y, Masuoka Y, Orita M, Sasamata M, Matsushime H, Furuichi K, Sakai T.; YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model.; Int J Oncol. 2008 Mar;32(3):545-55.

Takagi K, Sowa Y, Cevik OM, Nakanishi R, Sakai T.; CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells.; Int J Oncol. 2008 May;32(5):1105-10.

Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T.; Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.; Oncol Rep. 2008 Mar;19(3):721-7.

2007年

Yoshida T, Shiraishi T, Horinaka M, Nakata S, Yasuda T, Goda AE, Wakada M, Mizutani Y, Miki T, Nishikawa A, Sakai T.; Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.; Cancer Sci. 2007 Sep;98(9):1417-23. Epub 2007 Jul 23.

Yoshida T, Shiraishi T, Horinaka M, Wakada M, Sakai T.; Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin.; Oncol Rep. 2007 Nov;18(5):1239-42.

Yamaguchi T, Yoshida T, Kurachi R, Kakegawa J, Hori Y, Nanayama T, Hayakawa K, Abe H, Takagi K, Matsuzaki Y, Koyama M, Yogosawa S, Sowa Y, Yamori T, Tajima N, Sakai T.; Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor.; Cancer Sci. 2007 Nov;98(11):1809-16. Epub 2007 Sep 2.

Matsui TA, Sowa Y, Murata H, Takagi K, Nakanishi R, Aoki S, Yoshikawa M, Kobayashi M, Sakabe T, Kubo T, Sakai T.; The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line.; Int J Oncol. 2007 Oct;31(4):915-22.

Matsui TA, Murata H, Sakabe T, Sowa Y, Horie N, Nakanishi R, Sakai T, Kubo T.; Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.; Oncol Rep. 2007 Nov;18(5):1263-8.

Yokota T, Matsuzaki Y, Koyama M, Hitomi T, Kawanaka M, Enoki-Konishi M, Okuyama Y, Takayasu J, Nishino H, Nishikawa A, Osawa T, Sakai T.; Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells.; Cancer Sci. 2007 Sep;98(9):1447-53. Epub 2007 Jul 19.

Koyama M, Matsuzaki Y, Yogosawa S, Hitomi T, Kawanaka M, Sakai T.; ZD1839 induces p15INK4b and causes G1 arrest byinhibiting the MAPK/ERK pathway.; Mol Cancer Ther. 2007 May;6(5):1579-87.

Liu W, Nakamura H, Yamamoto T, Ikeda N, Saito M, Ohno M, Hara N, Imanishi H, Shimomura S, Yamamoto T, Sakai T, Nishiguchi S, Hada T.; Vitamin K2 inhibits the proliferation of HepG2 cells by up-regulating the transcription of p21 gene.; Hepatol Res. 2007 May;37(5):360-5.

Yoshida T, Maoka T, Das SK, Kanazawa K, Horinaka M, Wakada M, Satomi, Y,Nishino H, Sakai T.; Halocynthiaxanthin and peridinin, two dietary carotenoids, sensitize colon cancer cell lines to the death ligand TRAIL.; Molecular Cancer Research. 2007 Jun;5(6):615-25.

Li Y, Mizutani Y, Shiraishi T, Okihara K, Ukimura O, Kawauchi A, Nonomura N, Fukushima M, Sakai T, Miki T.; Prognostic significance of thymidylate synthase expression in patients with prostate cancer undergoing radical prostatectomy.; Urology. 2007 May;69(5):988-95.

Baritaki S, Huerta-Yepez S, Sakai T, Spandidos DA, Bonavida B.; Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1.; Mol Cancer Ther. 2007 Apr;6(4):1387-99

Kouhara J, Yoshida T, Nakata S, Horinaka M, Wakada M, Ueda Y, Yamagishi H, Sakai T. ; Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. ; International Journal of Oncology 2007 Mar;30(3):679-87.

Hitomi T, Matsuzaki Y, Yasuda S, Kawanaka M, Yogosawa S, Koyama M, Tantin D, Sakai T.; Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene.; FEBS Lett. 2007 Mar 20;581(6):1087-92. Epub 2007 Feb 14.

2006年

Izumi M, Yogosawa S, Aoki S, Watanabe H, Kamiyama J, Takahara Y, Sowa Y, Kobayashi M, Hosoi H, Sugimoto T, Sakai T.; A novel synthetic drug, LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells.; Int J Oncol. 2006 Jul;29(1):169-73.

Nakata S, Yoshida T, Shiraishi T, Horinaka M, Kouhara J, Wakada M, Sakai T.; 15-Deoxy-⊿12,14-prostaglandin J2 induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis.; Mol Cancer Ther. 2006 Jul;5(7):1827-35.

Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Sakai T.; The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand.; Mol Cancer Ther. 2006 Apr;5(4):945-51.

Matsui TA, Sowa Y, Yoshida T, Murata H, Horinaka M, Wakada M, Nakanishi R, Sakabe T, Kubo T, Sakai T.; Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.; Carcinogenesis. 2006 Mar 29; [Epub ahead of print]

Wilson AJ, Byun DS, Popova N, Murray LB, L’Italien K, Sowa Y, Arango D, Velcich A, Augenlicht LH, Mariadason JM.; Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer.; J Biol Chem. 2006 May 12;281(19):13548-58. Epub 2006 Mar 13.

Takahara Y, Yogosawa S, Maruyama S, Watanabe N, Yokoyama H, Fukasawa K, Sukenaga Y, Kamiyama J, Izumi M, Wakada M, Zhang H, Yoshizawa K, Kawa S, Nikaido T, Sakai T.; Lysocellin, a metabolite of the novel drug ‘alopestatin’, induces G1 arrest and prevents cytotoxicity induced by etoposide.; Int J Oncol. 2006 Apr;28(4):823-9.

Aoki S, Kong D, Suna H, Sowa Y, Sakai T, Setiawan A, Kobayashi M.; Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner.; Biochem Biophys Res Commun. 2006 Mar 31;342(1):101-6. Epub 2006 Feb 3.

2005年

Fischer C, Sanchez-Ruderisch H, Welzel M, Wiedenmann B, Sakai T, Andre S, Gabius HJ, Khachigian L, Detjen KM, Rosewicz S.; Galectin-1 interacts with theα5β1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.; J Biol Chem. 2005 Nov 4;280(44):37266-77. Epub 2005 Aug 16.

Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Yoshida T, Sakai T, Koyano T, Kam TS, Murata K, Sugahara K, Tsuruda K, Akamatsu N, Tsukasaki K, Masuda M, Takasu N, Kamihira S.; Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.; Blood. 2005 Oct 4; [Epub ahead of print]

Das SK, Hashimoto T, Shimizu K, Yoshida T, Sakai T, Sowa Y, Komoto A, Kanazawa K.; Fucoxanthin induces cell cycle arrest at G(0)/G(1) phase in human colon carcinoma cells through up-regulation of p21(WAF1/Cip1).; Biochim Biophys Acta. 2005 Oct 3; [Epub ahead of print]

Shimizu K, Das SK, Hashimoto T, Sowa Y, Yoshida T, Sakai T, Matsuura Y, Kanazawa K.; Artepillin C in Brazilian propolis induces G(0)/G(1) arrest via stimulation of Cip1/p21 expression in human colon cancer cells.; Mol Carcinog. 2005 Oct 13; [Epub ahead of print]

Yoshida T, Maeda A, Horinaka M, Shiraishi T, Nakata S, Wakada M, Yogosawa S, Sakai T.; Quercetin induces gadd45 expression through a p53-independent pathway.; Oncol Rep. 2005 Nov;14(5):1299-303.

Ishihara H, Yoshida T, Kawasaki Y, Kobayashi H, Yamasaki M, Nakayama S, Miki E, Shohmi K, Matsushima T, Tada S, Torikoshi Y, Morita M, Tamura S, Hino Y, Kamiyama J, Sowa Y, Tsuchihashi Y, Yamagishi H and Sakai T.;A new cancer diagnostic system based on a CDK profiling technology.; BBA. 2005 Sep 25;1741(3):226-33

Horinaka M, Yoshida T,Shiraishi T,Nakata S,Wakada M, Nakanishi R, Nishino H and Sakai T. ;The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells. ; Biochem Biophys res Commun. 2005 Aug 5;333(3):833-8.

Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Nakanishi R, Nishino H, Matsui H and Sakai T.; Luteolin induces apoptosis via death receptor 5 up-regulation in human malignant tumor cells. ; Oncogene. 2005 Nov 3;24(48):7180-9.

Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T.; Tunicamycin Enhances TRAIL-induced Apoptosis in Human Prostate Cancer Cells.; Cancer Res. 2005 Jul 15;65(14):6364-70.

Matsuzaki, Y., Koyama, M., Hitomi, T., Takaoka, Y., Kawanaka, M., and Sakai,T.;15-deoxy-D12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor.; Int J Oncol. 2005 Aug;27(2):497-503

Yoshida T, Shiraishi T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T.; Proteasome inhibitor MG132 induces Death Receptor 5 through CCAAT/Enhancer-binding protein homologous protein.; Cancer Res. 2005 Jul 1;65(13):5662-7.

Matsuzaki, Y., and Sakai, T.; INK4 family-A Promising Target for‘Gene-Regulating Chemoprevention’ and ‘Molecular-Targeting Prevention’ of Cancer-. Environmental Health and Preventive Medicine. 2005:10: 72-77.

Maeda T, Nagaoka Y, Kawai Y, Takagaki N, Yasuda C, Yogosawa S, Sowa Y, Sakai T, Uesato S.; Inhibitory effects of cancer cell proliferation by novel histone deacetylase inhibitors involve p21/WAF1 induction and G2/M arrest.; Biol Pharm Bull. 2005 May;28(5):849-53.

Murata K, Hattori M, Hirai N, Shinozuka Y, Hirata H, Kageyama R, Sakai T, Minato N.; Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1.; Mol Cell Biol. 2005 May;25(10):4262-71.

Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T.; Differential response at the hGABP/E4TF1 site of retinoblastoma gene promoter in human testicular seminoma cells.; Oncol Rep. 2005 May;13(5):871-4.

Takagaki N, Sowa Y, Oki T, Nakanishi R, Yogosawa S and Sakai T; Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway; Int J Oncol. 2005 Jan;26(1):185-9.

Ungerstedt JS, Sowa Y, Xu WS, Shao Y, Dokmanovic M, Perez G, Ngo L, Holmgren A, Jiang X, Marks PA.; Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors.; Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):673-8.

2004年

Matsuzaki Y, Koyama M, Hitomi T, Kawanaka M, Sakai T.; Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15(INK4b) gene.; FEBS Lett. 2004 Oct 8;576(1-2):137-40.

Oki T, Sowa Y, Hirose T, Takagaki N, Horinaka M, Nakanishi R, Yasuda C., Yoshida T, Kanazawa M, Satomi Y, Nishino H, Miki T and Sakai T; Genistein Induces Gadd45 Gene and G2/M Cell Cycle Arrest in the DU145 Human Prostate Cancer Cell Line; FEBS Lett., 577: 55-9, 2004.

Yokota T, Matsuzaki Y, Sakai T. ;Trichostatin A activates p18(INK4c) gene: differential activation and cooperation with p19(INK4d) gene.; FEBS Lett. 574: 171-5, 2004

Nakata S, Yoshida T, Horinaka M, Shiraishi T, Wakada M, Sakai T. ;Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells.; Oncogene. 23: 6261-71, 2004

Sakata R, Minami S, Sowa Y, Yoshida M, Tamaki T.; Trichostatin A activates the osteopontin gene promoter through AP1 site.; Biochem Biophys Res Commun. 315: 959-63, 2004.

Yokota T, Matsuzaki Y, Miyazawa K, Zindy F, Roussel MF, Sakai T. ;Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.; Oncogene. 23: 5340-9, 2004

Matsuzaki Y, Takaoka Y, Hitomi T, Nishino H, Sakai T. ;Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c).; Oncogene.23: 5409-5414, 2004

Yoshida, T., and Sakai, T., Promoter of TRAIL-R2 gene. ; Vitamins and Hormones, 67: 35-49, 2004

2003年

Hitomi T, Matsuzaki Y, Yokota T, Takaoka Y, Sakai T. p15(INK4b) in HDAC inhibitor-induced growth arrest.; FEBS Lett. 554: 347-50, 2003

Hirose T, Sowa Y, Takahashi S, Saito S, Yasuda C, Shindo N, Furuichi K, Sakai T. ;p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.; Oncogene. 22: 7762-73, 2003

Saito S, Takahashi S, Takagaki N, Hirose T, Sakai T. 15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells. Biochem Biophys Res Commun. 311:17-23, 2003

Kanazawa, M., Satomi, Y., Mizutani, Y., Ukimura, O., Kawauchi, A.,Sakai, T., Baba, M., Okuyama, T., Nishino, H., and Miki, T.;Isoliquiritigenin inhibits the growth of prostate cancer. ;European Urology, 43: 580-6, 2003

Bruemmer, D., Yin, F., Liu, J., Berger, J.P., Sakai, T., Blaschke, F.,Fleck, E., Van Herle, A.J., Forman, B.M., and Law, R.E. ;Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.;Circulation Research, 93: 38-47, 2003

Marabese, M., Vikhankaya, F., Rainelli, C., Sakai, T., and Broggini, M.; DNA damage induces transcriptional activation of p73 by removing C-EBPa repression on E2F1. Nucleic Acids Research, 31: 6624-32, 2003.

Matsuzaki, Y., Sowa, Y., Hirose, T., Yokota, T., and Sakai, T. Histone deacetylase inhibitors-Promising agents for “Gene-regulating chemoprevention” and Molecular-targeting preventionモ of cancer. Environmental Health and Preventive Medicine, 8: 157-60, 2003

2002年

Matsuzaki, Y., Miyazawa ,K., Yokota, T., Hitomi, T., Yamagishi, H., Sakai T. ;Molecular cloning and characterization of the human p19(INK4d) gene promoter. ; FEBS Lett. 517: 272-6, 2002

Maeda, A., Yoshida, T., Kusuzaki, K., Sakai, T. ; The characterization ofthe human Siah-1 promoter. ; FEBS Lett. 512: 223-6, 2002

Brooks, L.A., Sullivan, A., O’Nions, J., Bell, A., Dunne, B., Tidy, J.A., Evans, D.J., Osin, P., Vousden, K.H., Gusterson, B., Farrell, P.J., Storey, A., Gasco, M., Sakai, T., and Crook, T. ; E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia. ; Brit. J. Cancer 86: 263-8, 2002

2001年

Takakura M, Kyo S, Sowa Y, Wang Z, Yatabe N, Maida Y, Tanaka M, Inoue M.; Telomerase activation by histone deacetylase inhibitor in normal cells.; Nucleic Acids Res. 29: 3006-11, 2001.

Yoshida, T., Maeda, A., Tani, N., Sakai, T. ; Promoter structure and transcription initiation sites of the human Death Receptor 5/TRAIL-R2 gene.; FEBS Lett. 507: 381-5, 2001

Matikainen, T., Perez G.I., Jurisicova, A., Pru, J.K., Schlezinger, J.J., Ryu, H.Y., Laine, J., Sakai, T.,Korsmeyer, S.J., Casper, R.F., Sherr, D.H., Tilly, J.L. ; Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals.; Nature Genet. 28: 355-60, 2001

Takahashi, S., Saito, S., Ohtani, N., Sakai, T. Involvement of the Oct-1 regulatory element of the gadd45 promoter in the p53-independent response to ultraviolet irradiation. ; Cancer Res. 61: 1187-95, 2001

Kanemitsu, N., Kato, M.V., Bai, F., Miki, T., Inoue, T., Sakai, T.; Correlation between induction of the mac25 gene and anti-proliferative effects of 1,25(OH)2-D3 on breast cancer and leukemic cells. ; Int. J. Mol. Med., 7: 515-20, 2001

Onishi, K., Kato, M.V., Bai, F., Sakai, T. ; SMRT as a T3SF-binding protein.; Int. J. Oncol. 18: 985-9, 2001

2000年

Kanemitsu, N., Kato, M.V., Miki, T., Komatsu, S., Okazaki, Y., Hayashizaki, Y., Sakai, T.; Characterization of the promoter of the murine mac25 gene. ; Biochem. Biophys. Res. Commun. 279: 251-7, 2000

Huang, L., Sowa, Y., Sakai, T., Pardee, A.B. Activation of the p21/WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites.; Oncogene 19: 5712-9, 2000

Sowa, Y., Sakai, T. Butyrate as a model for “gene-regulating chemoprevention and chemotherapy.”. ; Biofactors 12: 283-7, 2000

Evdokiou , A., Raggatt, L.-J., Sakai, T., Findlay, D.M., Identification of a novel calcitonin-response element in the promoter of the human p21WAF1/CIP1 gene. ; J. Mol. Endocrinol. 25: 195-206, 2000

1999年

Ueno, M., Masutani, H., Arai, R.J., Yamauchi, A., Hirota, K., Sakai, T., Inamoto, T., Yamaoka, Y., Yodoi, J., Nikaido, T. ; Thioredoxin-dependent redox regulation of p53-mediated p21 activation. ; J. Biol. Chem. 274: 35809-15,1999

Inoue, T., Kamiyama, J., Sakai, T.; Sp1 and NF-Y synergistically mediate the effect of vitamin D3 in the p27Kip1 gene promoter that lacks vitamin D response elements. ; J. Biol. Chem. 274: 32309-17,1999

Igata, E., Inoue, T., Ohtani-Fujita, N., Sowa, Y., Tsujimoto, Y., Sakai, T.; Molecular cloning and functional analysis of the murine bax gene promoter. ; Gene 238: 407-15,1999

Ding, Y., Inoue, T., Kamiyama, J., Tamura, Y., Ohtani-Fujita, N., Igata, E., Sakai, T.; Molecular cloning and functional characterization of the upstream promoter region of the human p73 gene. ;DNA Res., 6: 347-51,1999.

Ding, Y., Matsukawa, Y., Ohtani-Fujita, N., Kato, D., Dao, S., Fujii, T., Naito, Y., Yoshikawa, T,. Sakai, T., and Rosenthal, G.A. ; Growth inhibition of A549 human lung adenocarcinoma cells by L-canavanine is associated with p21/WAF1 induction. ; Jpn. J. Cancer Res., 90: 69-74, 1999.

Kamiyama, J., Inoue, T., Ohtani-Fujita, N., Minami, S., Yamagishi, H., Sakai, T. ;The ubiquitous transcription factor NF-Y positively regulates the transcription of human p27Kip1 through a CCAAT box located in the 5-upstream region of the p27Kip1 gene. ; FEBS Lett., 455: 281-5, 1999.

Sowa, Y., Orita, T., Minamikawa-Hiranabe, S., Mizuno, T., Nomura, H., Sakai, T. ;Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. ; Cancer Res.59: 4266-70, 1999.

Sowa, Y., Orita, T., Hiranabe-Minamikawa, S., Nakano, K., Mizuno, T., Nomura, H., and Sakai, T. Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. Ann. N.Y. Acad. Sci. 886, 195-9, 1999

1998年

Matsumoto, T., Sowa, Y., Ohtani-Fujita, N., Tamaki, T., Takenaka, T., Kuribayashi, K., Sakai, T. ; p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. ; Cancer Lett.129: 61-8, 1998.

Ohtani-Fujita, N, Minami, S., Mimaki, S., Dao, S., Sakai, T. ; p53 independent activation of the gadd45 promoter by ⊿12-prostaglandin J2.; Biochem. Biophys. Res. Commun., 251: 648-52, 1998.

Bai, F., Matsui, T., Ohtani-Fujita, N., Matsukawa, Y., Ding, Y., Sakai, T. ; Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. ; FEBS Lett., 437: 61-64 , 1998.

Kato, D., Miyazawa, K., Ruas, M., Starborg, M., Wada, I., Oka, T., Sakai, T., Peters, G., and Hara, E. ;Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts. ; FEBS Lett., 27: 203-208, 1998.

1997年

Matsukawa, Y., Nishino, H., Okuyama, Y., Matsui, T., Matsumoto, T., Matsumura, S., Shimizu, Y., Sowa, Y., and Sakai, T. Effects of quercetin and/or restraint stress on formation of aberrant crypt foci induced by azoxymethane in rat colons. Oncology, 54: 118-121, 1997.

Nakano, K., Mizuno, T., Sowa, Y., Orita, T., Yoshino, T., Okuyama, Y., Fujita, T., Ohtani-Fujita, N., Matsukawa, Y., Tokino, T., Yamagishi, H., Oka, T., Nomura, H., and Sakai, T. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. The Journal of Biological Chemistry, 272 : 22199-22206, 1997.

Minami, S., Ohtani-Fujita, N., Igata, E., Tamaki, T., and Sakai, T. Molecular cloning and characterization of the human p27Kip1 gene promoter. FEBS Letters, 411: 1-6, 1997.

Sowa, Y., Shiio, Y., Fujita, T., Matsumoto, T., Okuyama, Y., Kato, D., Inoue, J., Sawada, J., Goto, M., Watanabe, H., Handa, H., and Sakai, T. Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Cancer Research, 57: 3145-8, 1997.

Matsui, T., Matsukawa, Y., Sakai, T., Nakamura, K., Aoike, A., Kawai, K. Ammonia inhibits proliferation and cell cycle progression at S-phase in human gastric cells. Digestive Diseases and Sciences, 42: 1394-9, 1997.

Sowa Y, Orita T, Minamikawa S, Nakano K, Mizuno T, Nomura H, Sakai T. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochemical and Biophysical Research Communications, 241: 142-50, 1997.

Ohtani-Fujita, N., Dryja, T. P., Rapaport, J.M., Fujita, T., Matsumura, S., Ozasa, K., Watanabe, Y., Hayashi, K., Maeda, K., Kinoshita, S., Matsumura, T., Ohnishi, Y., Hotta, Y., Takahashi, R., Kato, M.V., Ishizaki, K., Sasaki, M.S., Horsthemke, B., Minoda, K., and Sakai T. Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma. Cancer Genetics and Cytogenetics, 98 43-9, 1997.

1996年

Fujita, T., Ohtani-Fujita, N., and Sakai, T. Identification of an RB-responsive region in the 5′ untranslated region of the RB gene. Cancer Letters, 101 : 149-57, 1996.

Okuyama, Y., Sowa, Y., Fujita, T., Mizuno, T., Nomura, H., Nikaido, T., Endo, T., and Sakai, T. ATF site of human RB gene promoter is a responsive element of myogenic differentiation. FEBS Letters, 397: 219-24, 1996.

Nikaido, T., Ono, K., Yamamoto, M., Sakai, T., and Magami, Y. Cell cycle regulation in T-cells.Matsumoto Symposium: Epithelial & Lymphoid Cell Cohabitation for Mucosal Immunity. Amsterdam : Elsevier Science, (in the press)

Matsukawa, Y., Sato, F., and Sakai, T. Effects of flavonoids on cell cycle and differentiation in cancer cells.Proceedings of International Conference on Food Factors-Chemistry and Cancer Prevention- (Osawa, T., editor). Tokyo : Springer-Verlag, (in the press).

1995年

Matsui, T., Matsukawa, Y., Sakai, T., Nakamura, K, Aoike, A, and Kawai, K. Effect of ammonia on cell-cycle progression of human gastric cancer cells. Eur J Gastroenterol Hepatol, 7, S79-S81, 1995.

1994年

Yamamoto, M., Yoshida, M., Ono, K., Fujita, T., Ohtani-Fujita, N., Sakai, T., and Nikaido, T. Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34cdc2 expression and normal p53 suppresses cyclin A expression. Experimental Cell Research, 210 : 94-101, 1994

Osifchin, N.E., Jiang, D., Ohtani-Fujita, N., Fujita, T., Carroza, M., Kim, S.-J., Sakai, T., and Robbins, P.D. Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter. The Journal of Biological Chemistry, 269 : 6383-9, 1994.

Ohtani-Fujita, N., Fujita, T., Takahashi, R., Robbins, P.D., Dryja, T.P., and Sakai, T. A silencer element in the retinoblastoma tumor-suppressor gene. Oncogene, 9 : 1703-11, 1994.

Savoysky, E., Mizuno, T., Sowa, Y., Watanabe, H., Sawada, J.-i., Nomura, H., Ohsugi, Y., Handa, H., and Sakai, T. The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family. Oncogene, 9: 1839-46, 1994.

Sato, F., Matsukawa, Y., Matsumoto, K., Nishino, H., and Sakai, T. Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochemical and Biophysical Research Communications, 204: 578-84, 1994.

Nikaido, T., Ono, K., Yamamoto, M., Sakai,T., and Magami, Y. Cell cycle regulation in normal versus leukemic T cells. The Cell Cycle: Regulators, Targets, and Clinical Applications (Hu, V.W., editor). New York and London : Plenum Press, 347-57, 1994

1993年

Ohtani-Fujita, N., Fujita, T., Aoike, A., Osifchin, N.E., Robbins, P.D., and Sakai, T. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene, 8: 1063-7, 1993.

Matsukawa, Y., Marui, N., Sakai, T., Satomi, Y., Yoshida, M., Matsumoto, K., Nishino, H., and Aoike, A. Genistein arrests cell cycle progression at G2-M. Cancer Research, 53: 1328-31, 1993

Yamamoto, M., Marui, N., Sakai, T., Morii, N., Kozaki, S., Ikai, K., Imamura, S., and Narumiya, S. ADP-ribosylation of the rho A gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene, 8: 1449-55, 1993

1992年

Yoshida, M., Marui, N., Sakai, T., Hosokawa, N., Matsukawa, Y., Aoike, A., and Kawai, K. Reversible arrest of proliferation of the gastric cancer cells in the G1 phase by quercetin.Cytoprotection and Cytobiology (Tobe, T., editor),Tokyo : Kanishobo, 8, 185-91, 1992.

1991年

Marui, N., Nishino, H., Sakai, T., Aoike, A., Kawai, K., and Fukushima, M. ⊿12-prostaglandin J2 mimics heat shock in inducing cell cycle arrest at G1 phase. Biochemical and Biophysical Research Communications, 179: 1662-9, 1991.

Sakai, T., Toguchida, J., Ohtani, N., Yandell, D.W., Rapaport, J.M., and Dryja, T.P. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. The American Journal of Human Genetics, 48: 880-8, 1991.

Sakai, T., Ohtani, N., McGee, T.L., Robbins, P.D., and Dryja, T.P. Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene. Nature, 353: 83-6, 1991.

1990年

Yoshida, M., Sakai, T., Hosokawa, N., Marui, N., Matsumoto, K., Fujioka, A., Nishino, H., and Aoike, A. The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Letters, 260: 10-3, 1990.

Marui, N., Sakai, T., Hosokawa, N., Yoshida, M., Aoike, A., Kawai, K., Nishino, H., and Fukushima, M. N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. FEBS Letters, 270: 15-8, 1990.

Hosokawa, N., Hosokawa, Y., Sakai, T., Yoshida, M., Marui, N., Nishino, H., Kawai, K., and Aoike, A. Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-kDa protein, in human colon cancer cells. International Journal of Cancer, 45: 1119-24, 1990.

Hosokawa, N., Hirayoshi, K., Nakai, A., Hosokawa, Y., Marui, N., Yoshida, M., Sakai, T., Nishino, H., Aoike, A., Kawai, K., and Nagata, K. Flavonoids inhibit the expression of heat shock proteins. Cell Structure and Function, 15: 393-401, 1990.

1989年

Sakai, T., Aoike, A., Marui, N., Kawai, K., Nishino, H., and Fukushima, M. Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or ⊿12– prostaglandin J2 on human osteosarcoma cells. Cancer Research, 49: 1193-6, 1989.

Murakoshi, M., Takayasu, J., Kimura, O., Kohmura, E., Nishino, H., Iwashima, A., Okuzumi, J., Sakai, T., Sugimoto, T., Imanishi, J., and Iwasaki, R. Inhibitory effects of α-carotene on proliferation of the human neuroblastoma cell line GOTO. Journal of the National Cancer Institute, 81: 1649-52, 1989.

Sakai, T., Aoike, A., Marui, N., Nishino, H., Fukushima, M., and Kawai, K. Cytoprotective effect of cycloheximide against cytotoxicity induced by anti-tumor drugs.Cytoprotection and Cytobiology (Nagamachi, Y., editor). London : Cytomedica 6, 171-6, 1989.

和文総説・著書

曽和義広, 酒井敏行. がん抑制遺伝子とヘルスフード. 水島裕監修. アンチエイジング・ヘルスフード. 東京:サイエンスフォーラム, 261-7, 2008.

堀中真野, 酒井敏行. 食品成分による癌の「分子標的予防法」の開発. FFIジャーナル213:537-44, 2008.

曽和義広, 酒井敏行. 発癌の分子機構に基づいた癌の“分子標的予防”研究. 医学のあゆみ 227:147-8, 2008.

与五沢真吾.  田村隆明、山本雅之編. 転写因子・転写制御キーワードブック. 東京:羊土社, 132-3, 225, 233, 261, 303-4, 306, 2006.

吉田達士.  田村隆明、山本雅之編. 転写因子・転写制御キーワードブック. 東京:羊土社, 113-4, 154-5, 174, 243-4, 2006.

与五沢真吾、西野輔翼、酒井敏行. ヒトがん化学予防研究への応用. がん分子標的治療 2 : 60-6, 2004

曽和義広、酒井敏行. 癌の化学療法・予防法へのゲノミクスの利用. 生体の科学 54: 386-92, 2003.

曽和義広、酒井敏行. 癌の遺伝子調節化学予防法ー癌の「分子標的予防法」のモデルとしてー 日本衛生学雑誌 58: 267-4, 2003.

神山順、酒井敏行. 遺伝子調節化学予防 発癌の遺伝子異常に基づいた新しい予防法の開発. 医学のあゆみ 204: 3-6, 2003.

酒井敏行、神山順、曽和義広. 発癌感受性に対する食物成分による分子修飾. 癌の臨床 46: 1421-4, 2000.

曽和義広、酒井敏行. p53とp21/WAF1を標的とした分子治療. 現代医療 32:2406-10, 2000.

酒井敏行. がんの遺伝子調節化学予防(化学療法). 西野輔翼編. がん化学予防の最前線. 大阪:医療ジャーナル社, 95-103, 2000.

酒井敏行. 悪性腫瘍. 各論3 成人病・生活習慣病, アレルギー疾患 molecular pathogenesis から chemopreventionまで. 分子予防医学. 東京、医学書院、254-9, 1999.

曽和義広、酒井敏行. がん予防-分子レベルのメカニズム. 大澤 俊彦、大東肇、吉川敏一. 監修. がん予防食品:フードファクターの予防医学への応用.  東京、株式会社シーエムシー、 53-64, 1999.

酒井敏行. 要因観察方法の推移.特集/日本がん疫学研究会の20年と課題. 癌の臨床.44;35-38, 1998.

中野 且敬、山岸 久一、岡 隆宏、酒井 敏行. 遺伝子調節による予防. 日本外科学会雑誌. 99:373-8, 1998.

内藤祐二、酒井敏行. 胃癌・消化性潰瘍の遺伝について. 内科診療Q&A. 名古屋:六法出版社, 174-7, 1997.

酒井敏行. 分子癌疫学-その現状および今後の可能性.第65回日本衛生学会奨励賞受賞講演総説.日本衛生学雑誌 50:1036-46, 1996.

酒井敏行. p53によるRB遺伝子の発現制御.実験医学 13:45-8, 1995.

藤田直子、酒井敏行. RB遺伝子のエピジェネティックな異常による発癌の可能性.実験医学 13:80(1448)-82(1450), 1995.

酒井敏行. 癌予防と早期発見へのアプローチ-癌予防法の開発.予防医学と分子生物学.公衆衛生 59:832-3, 1995.

酒井敏行. 遺伝学のトピックス、癌抑制遺伝子とは? の項担当.眼科診療プラクティス、眼科診療に役立つ遺伝学(大庭紀雄編集).東京:文光堂,114-5, 1995.

松川義純、酒井敏行、佐藤婦美子、川井啓市.フラボノイド類の細胞周期に及ぼす影響とがん予防.がん予防食品の開発(大澤俊彦編集).東京:シーエムシー社,101-109, 1995.

酒井敏行.遺伝子調節化学予防の基礎的研究.がん増殖の抑制と食品との関連(川井啓市監修、青池 晟、渡邊能行、酒井敏行編集).東京:ライフサイエンス出版,11-3, 1995.

松川義純、酒井敏行、佐藤婦美子、川井啓市.フラボノイドによる発がん抑制およびそのメカニズム.がん増殖の抑制と食品との関連(監修、青池 晟、渡邊能行、酒井敏行編集).東京:ライフサイエンス出版,53-6, 1995.

酒井敏行、川井啓市. 第V 章、胃癌、b. 遺伝子レベルでの発生論の項担当.胃-形態とその機能(第2版)(川井啓市編集).東京:医学書院,326-30, 1994.

酒井敏行、川井啓市. 公衆衛生学的に有用な新しい癌体質診断法の開発.病態生理 13:468-72, 1994.

酒井敏行:シグナル伝達異常と疾病.IV. 転写因子RBと網膜芽細胞腫.臨床科学 30:1242-8, 1994.

松井亮好、松川義純、酒井敏行、中村圭也、青池晟、川井啓市.アンモニアのヒト胃癌培養細胞の細胞周期に与える影響.Cyto-protection and biology(中村紀夫編集).東京:癌と化学療法社,12, 15-8, 1994.

松川義純、酒井敏行、東健、青池晟、川井啓市. 消化性潰瘍の遺伝子解析.臨床科学 29:862-6, 1993.

酒井敏行. RB遺伝子のプロモーター構造およびその不活性化機構.癌抑制遺伝子-その作用機構に迫る(野田亮編集).東京:羊土社,10 ,16(2142)-21(2147), 1992.

吉田光範、丸井伸行、酒井敏行、細川暢子、松川義純、青池 晟、川井啓市.植物性フラボノイド(quercetin) のヒト胃癌培養細胞増殖に対する抑制効果-特に細胞周期に及ぼす影響について-.Cyto-protection & biology(戸部隆吉ら編).東京:蟹書房,8,209-16, 1990.